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Download Disorders of Lipid Metabolism djvu

by G.V. Marinetti

Author: G.V. Marinetti
Subcategory: Medicine
Language: English
Publisher: Springer; 1 edition (March 31, 1990)
Pages: 240 pages
Category: Medicine
Rating: 4.6
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Authors: Marinetti, . Bibliographic Information.

Authors: Marinetti, . price for USA in USD (gross). ISBN 978-1-4615-9564-9. Digitally watermarked, DRM-free. Plenum Press, New York.

The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. 246-7 } }. Guido V. Marinetti.

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students.

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glyco- lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins.

Lipids are large, water-insoluble molecules that have a variety of biological functions, including storing energy and serving as components of cellular membranes and lipoproteins. Cells that line the small intestine absorb dietary lipids and process them into lipoprotein particles that enter the circulation via the lymphatic system for eventual uptake by the liver. Triglycerides, cholesterol, and fat-soluble vitamins are transported through the blood by these lipoprotein particles.

Diagnosis is by finding low levels of LDL cholesterol and apo B on a serum lipid profile

Hypolipidemia is defined as a total cholesterol (TC) < 120 mg/dL (< . mmol/L) or low-density lipoprotein (LDL) cholesterol < 50 mg/dL (< . mmol/L). Causes may be primary (genetic) or secondary. Diagnosis is by finding low levels of LDL cholesterol and apo B on a serum lipid profile. mia and are distinguished from one another by family history.

Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. Lipogenesis is the process of synthesizing these fats. The majority of lipids found in the human body from ingesting food are triglycerides and cholesterol.

They play an important role in the pathogenesis of atherosclerosis and can be effectively treated by lifestyle changes and drugs.

For the past 30 years I have been teaching lipid biochemistry to'inedical students, graduate students, and undergraduate students. The major topics covered in my courses were fatty acids, prostaglandins, leukotrienes, phospholipids, glyco­ lipids, triacylglycerols, cholesterol, bile acids, and plasma lipoproteins. Empha­ sis was placed on the regulation and disorders of lipid metabolism. The latter included hyperlipidemias, atherosclerosis, and alcohol-induced liver damage. In this volume, I have chosen to focus on the disorders of lipid metabolism at a level appropriate both for medical students and for graduate and undergradu­ ate students majoring in the biological sciences. The biochemistry, nutrition, genetics, and cell biology aspects of lipids and lipid metabolism will be covered as they relate to lipid disorders. I am not aware of any textbook that integrates the disorders of lipid metabolism in this manner. Chapter 1 includes a brief discussion of the basic structures, properties, and metabolism of lipids. This chapter is not very detailed, since the material covered is available in basic textbooks on biochemistry. The major fpcus of this volume is the various lipid disorders, with emphasis on polyunsaturated fatty acids, the molecular biology and pathogenesis of the hyperlipidemias, dietary and drug therapy for the hyperlipidemias, and alcohol-induced liver damage. The material presented has been obtained from several textbooks on biochemistry and from a variety of recent articles in the scientific literature.