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by Derek J. Chadwick,Jamie A. Goode

Author: Derek J. Chadwick,Jamie A. Goode
Subcategory: Biological Sciences
Language: English
Publisher: Wiley; 1 edition (April 28, 2008)
Pages: 248 pages
Category: Math and Science
Rating: 4.6
Other formats: lrf mobi txt mbr

Start by marking The Biology of Extracellular Molecular Chaperones as Want to Read .

Start by marking The Biology of Extracellular Molecular Chaperones as Want to Read: Want to Read savin. ant to Read. our current knowledge of cell stress response and molecular chaperones the changing paradigms of protein trafficking and function cell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules the role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.

The Novartis Foundation is an international scientific and educational charity which promotes the study and general .

Chair: Péter Csermely. Request permission to reuse content from this site. Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5–7 June 2007. This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley.

266 p. The Ciba Foundation Symposia have a well-deserved reputation for providing excellent compendiums of knowledge in particular fields. This tradition is being carried on by the Novartis Foundation since the Ciba/ Sandoz merger in 1996. This volume on sex determination follows the hallowed format. In a meeting proposed by Peter Koopman, organized by Derek Chadwick, and chaired by Roger Short, a number of experts on the molecular biology, genetics, and evolution of sex determining mechanisms in vertebrates gathered

Novartis Foundation Symposium, No. 29.

Novartis Foundation Symposium, No. 291. Novartis Foundation Symposia Description: Novartis Foundation Symposium 291 The Biology of Extracellular Molecular Chaperones Chair: Péter Csermely The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. Contents: Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5 7 June 2007. Graham Pockley Péter Csermely Chair's introduction.

The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection

The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.

This book brings together contributions from key investigators in the area of pathological pain.

Annals of Neurology, August 2005). This book brings together contributions from key investigators in the area of pathological pain.

Molecular Biology of the Cell is a cellular and molecular biology textbook published by Garland Science and currently authored by Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter

Molecular Biology of the Cell is a cellular and molecular biology textbook published by Garland Science and currently authored by Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts and Peter Walter.

The heat shock, or cell stress, response was first identified inthe polytene chromosomes of Drosophila. This was laterrelated to the appearance of novel proteins within stressed cells,and the key signal stimulating this appearance was identified asthe presence of unfolded proteins within the cell. It is now knownthat this is a key mechanism enabling cells to survive a multitudeof physical, chemical and biological stresses.

Since the promulgation of the ‘molecular chaperone’concept as a general cellular function to control the process ofcorrect protein folding, a large number of molecular chaperones andprotein folding catalysts have been identified, and it has beenrecognized that not all molecular chaperones are stress proteinsand vice versa. The discovery of molecular chaperones as foldingproteins went hand-in-hand with their recognition as potentimmunogens in microbial infection. It was subsequently shown thatadministration of molecular chaperones such as Hsp60, Hsp70 orHsp90 could inhibit experimental autoimmune diseases andcancer.

More recently evidence has accumulated to show that certainmolecular chaperones are also present on the surface of cells or inextracellular fluids. A new paradigm is emerging: at least somemolecular chaperones are secreted proteins with pro- oranti-inflammatory actions, regulating the immune response in humandiseases such as coronary heart disease, diabetes and rheumatoidarthritis. In addition to having direct effects on cells, molecularchaperones can bind peptides and present them to T cells tomodulate immune responses. This may be significant in the treatmentof cancer.

This is the first book bringing leading researchers in thisfield together to review and discuss:

our current knowledge of cell stress response and molecularchaperonesthe changing paradigms of protein trafficking and functioncell stress proteins as immunomodulators and pro- andanti-inflammatory signalling moleculesthe role of these proteins in various chronic diseases andtheir potential as preventative or therapeutic agents.

The Biology of Extracellular Molecular Chaperones is ofparticular interest to immunologists, cell and molecularbiologists, microbiologists and virologists, as well as clinicalresearchers working in cardiology, diabetes, rheumatoid arthritisand other inflammatory diseases.